“Ukatamanga weka utamangisa, tikatamanga awili, tifikapatali - When you run alone, you run fast. When you run together, you run far Zambian Proverb

UNZA-UCLMS

Research and Training Programme

2016

Host-directed therapies for multidrug resistant tuberculosis. Zumla A, Maeurer M. Int J Mycobacteriol. 2016 Dec;5 Suppl 1:S21-S22.


Short-term economic impact of the Zika virus outbreak. Macciocchi D, Lanini S, Vairo F, Zumla A, Figueiredo LT, Lauria FN, Strada G, Brouqui P, Puro V, Krishna S, Kremsner P, Scognamiglio P, Köhler C, Nicastri E, Di Caro A, Cieri RM, Ioannidis JP, Kobinger G, Burattini MN, Ippolito G. New Microbiol. 2016 Oct;39(4):287-289.


Learning from epidemiological, clinical, and immunological studies on Mycobacterium africanum for improving current understanding of host-pathogen interactions, and for the development and evaluation of diagnostics, host-directed therapies, and vaccines for tuberculosis. Zumla A, Otchere ID, Mensah GI, Asante-Poku A, Gehre F, Maeurer M, Bates M, Mwaba P, Ntoumi F, Yeboah-Manu D. Int J Infect Dis. 2016 Dec 12.


The Middle East Respiratory Syndrome Coronavirus - A Continuing Risk to Global Health Security. Azhar EI, Lanini S, Ippolito G, Zumla A. Adv Exp Med Biol. 2016 Dec 14.


Shifting from tuberculosis control to elimination: Where are we? What are the variables and limitations? Is it achievable? Centis R, D'Ambrosio L, Zumla A, Migliori GB. Int J Infect Dis. 2016 Dec 1.


Tuberculosis eradication versus control. Schito M, Hanna D, Zumla A.Int J Infect Dis. 2016 Nov 18.


European policies in the management of tuberculosis among migrants. D'Ambrosio L, Centis R, Dara M, Solovic I, Sulis G, Zumla A, Migliori GB.Int J Infect Dis. 2016 Nov 9.


WHO recommendations for multidrug-resistant tuberculosis - Authors' reply. Sotgiu G, Tiberi S, D'Ambrosio L, Centis R, Zumla A, Migliori GB. Lancet. 2016 Nov 5;388(10057):2234-2235.

Impact of Infectious Disease Epidemics on Tuberculosis Diagnostic, Management and Prevention Services: Experiences and Lessons from the 2014-2015 Ebola Virus Disease Outbreak in West Africa. Ansumana R, Keitell S, Roberts GM, Ntoumi F, Petersen E, Ippolito G, Zumla A. Int J Infect Dis. 2016 Nov 3.

Classifying new anti-TB drugs: rationale and future perspectives. Tiberi S, Scardigli A, Centis R, D'Ambrosio L, Muñoz-Torrico M, Salazar-Lezama MÁ, Spanevello A, Visca D, Zumla A, Migliori GB, Luna JA. Int J Infect Dis. 2016 Nov 3.

Applicability of the shorter 'Bangladesh regimen' in high MDR-TB settings. Sotgiu G, Tiberi S, Centis R, D'Ambrosio L, Fuentes Z, Zumla A, Migliori GB. Int J Infect Dis. 2016 Nov 2.

Recent developments in the diagnosis and management of tuberculosis. Sulis G, Centis R, Sotgiu G, D'Ambrosio L, Pontali E, Spanevello A, Matteelli A, Zumla A, Migliori GB. NPJ Prim Care Respir Med. 2016 Nov 3;26:16078.

Vitamin D as Adjunctive Host-Directed Therapy in Tuberculosis: A Systematic Review. Wallis RS, Zumla A. Open Forum Infect Dis. 2016 Sep 7;3(3).

Preventing the spread of multidrug-resistant tuberculosis and protecting contacts of infectious cases. Fox GJ, Schaaf HS, Mandalakas A, Chiappini E, Zumla A, Marais BJ. Clin Microbiol Infect. 2016 Aug 31.

Infectious diseases epidemic threats and mass gatherings: refocusing global attention on the continuing spread of the Middle East Respiratory syndrome coronavirus (MERS-CoV). Zumla A, Alagaili AN, Cotten M, Azhar EI. BMC Med. 2016 Sep 7;14(1):132.

Lujo viral hemorrhagic fever: considering diagnostic capacity and preparedness in the wake of recent Ebola and Zika virus outbreaks. Edgar Simulundu, Aaron S. Mweene, Katendi Changula, Mwaka Monze, Elizabeth Chizema, Peter Mwaba, Ayato Takada, Guiseppe Ippolito, Francis Kasolo, Alimuddin Zumla, Matthew Bates Rev. Med. Virol. 2016; 1–9 PDF

Faster for less: the new "shorter" regimen for multidrug-resistant tuberculosis. Sotgiu G, Tiberi S, D'Ambrosio L, Centis R, Alffenaar JW, Caminero JA, Abdo Arbex M, Alarcon Guizado V, Aleksa A, Dore S, Gaga M, Gualano G, Kunst H, Payen MC, Roby Arias AJ, Skrahina A, Solovic I, Sulis G, Tadolini M, Zumla A, Migliori GB; International Carbapenem Study Group. Eur Respir J. 2016 Sep 1.

Hepatitis C: Global Epidemiology and Strategies for Control. Lanini S, Easterbrook PJ, Zumla A, Ippolito G. Clin Microbiol Infect. 2016 Aug 10.

Implementation and Operational Research: Clinical Impact of the Xpert MTB/RIF Assay in Patients With Multidrug-Resistant Tuberculosis. Padayatchi N, Naidu N, Yende-Zuma N, OʼDonnell MR, Naidoo K, Augustine S, Zumla A, Loveday M.J Acquir Immune Defic Syndr. 2016 Sep 1;73(1):e1-7.

Burden of respiratory tract infections at post mortem in Zambian children. Bates M, Shibemba A, Mudenda V, Chimoga C, Tembo J, Kabwe M, Chilufya M, Hoelscher M, Maeurer M, Sinyangwe S, Mwaba P, Kapata N, Zumla A. BMC Med. 2016 Jul 1;14(1):99. PDF

WHO recommendations on shorter treatment of multidrug-resistant tuberculosis. Sotgiu G, Tiberi S, D'Ambrosio L, Centis R, Zumla A, Migliori GB. Lancet. 2016 Jun 18;387(10037):2486-7.

'Sample-in, answer-out'? Evaluation and comprehensive analysis of the Unyvero P50 pneumonia assay. Personne Y, Ozongwu C, Platt G, Basurto-Lozada P, Shamin M, Gant VA, Zumla A, Enne VI. Diagn Microbiol Infect Dis. 2016 Jun 14.

The annual Hajj pilgrimage - minimizing the risk of ill health in pilgrims from Europe and opportunity for driving the best prevention and health promotion guidelines. Shafi S, Dar O, Khan M, Khan M, Azhar EI, McCloskey B, Zumla A, Petersen E.
Int J Infect Dis. 2016 Jun 22

Pathogens, prejudice, and politics: the role of the global health community in the European refugee crisis. Khan MS, Osei-Kofi A, Omar A, Kirkbride H, Kessel A, Abbara A, Heymann D, Zumla A, Dar O. Lancet Infect Dis. 2016 Jun 20.

Efficacy and Safety of 'Fixed Dose' versus 'Loose' Drug Regimens for Treatment of Pulmonary Tuberculosis in Two High TB-Burden African Countries: A Randomized Controlled Trial. Aseffa A, Chukwu JN, Vahedi M, Aguwa EN, Bedru A, Mebrahtu T, Ezechi OC, Yimer G, Yamuah LK, Medhin G, Connolly C, Rida W, Aderaye G, Zumla AI, Onyebujoh PC; 4FDC Study Group. PLoS One. 2016 Jun 20;11(6):

What is the experience from previous mass gathering events? Lessons for Zika virus and the Olympics 2016. Zumla A, Heymann D, McCloskey B, Bin Saeed AA, Dar O, Al Otabi B, Perlmann S, Gautret P, Roy N, Blumberg L, Azhar EI, Barbeschi M, Memish Z, Petersen E. Int J Infect Dis. 2016 Jun 15.

Hosting of mass gathering sporting events during the 2013-2016 Ebola virus outbreak in West Africa: experience from three African countries. Blumberg L, Regmi J, Endricks T, McCloskey B, Petersen E, Zumla A, Barbeschi M. Int J Infect Dis. 2016 Jun 15.

Potential of immunomodulatory agents as adjunct host-directed therapies for multidrug-resistant tuberculosis. Zumla A, Rao M, Dodoo E, Maeurer M. BMC Med. 2016 Jun 15;14(1):89.

Zika virus and microcephaly: is the correlation causal or coincidental? Liuzzi G, Puro V, Lanini S, Vairo F, Nicastri E, Capobianchi MR, Di Caro A, Piacentini M, Zumla A, Ippolito G. New Microbiol. 2016 Apr;39(2):83-5.

Zika virus in saliva-New challenges for prevention of human to human transmission. Liuzzi G, Nicastri E, Puro V, Zumla A, Ippolito G. Eur J Intern Med. 2016 May 11.

Optimizing the benefits of pneumococcal vaccination in the Kingdom of Saudi Arabia. Azhar EI, Zumla A. Ann Thorac Med. 2016 Apr-Jun;11(2):91-2.

Post-caesarean section surgical site infections at a Tanzanian tertiary hospital: a prospective observational study. De Nardo P, Gentilotti E, Nguhuni B, Vairo F, Chaula Z, Nicastri E, Nassoro MM, Bevilacqua N, Ismail A, Savoldi A, Zumla A, Ippolito G. J Hosp Infect. 2016 Mar 11.

Exposed, but Not Protected: More Is Needed to Prevent Drug-Resistant Tuberculosis in Healthcare Workers and Students. von Delft A, Dramowski A, Sifumba Z, Mosidi T, Xun Ting T, von Delft D, Zumla A. Clin Infect Dis. 2016 May 15;62 Suppl 3:S275-80.

Active Screening and Surveillance in the United Kingdom for Middle East Respiratory Syndrome Coronavirus in returning travellers and pilgrims from the Middle East - a prospective descriptive study for the period 2013- 2015. Atabani SF, Wilson S, Overton-Lewis C, Workman J, Kidd IM, Petersen E, Zumla A, Smit E, Osman H. Int J Infect Dis. 2016 Apr 23.

To have Sepsis or to being Septic-is the difference between these clinical conditions important? Petersen E, Zumla A. Int J Infect Dis. 2016 Apr 23.

Understanding community-acquired respiratory tract infections: new concepts of disease pathogenesis and new management strategies. Niederman MS, Zumla A. Curr Opin Pulm Med. 2016 May;22(3):193-5.

Longitudinal characterization of dysfunctional T cell-activation during human acute Ebola infection. Agrati C, Castilletti C, Casetti R, Sacchi A, Falasca L, Turchi F, Tumino N, Bordoni V, Cimini E, Viola D, Lalle E, Bordi L, Lanini S, Martini F, Nicastri E, Petrosillo N, Puro V, Piacentini M, Di Caro A, Kobinger GP, Zumla A, Ippolito G, Capobianchi MR. Cell Death Dis. 2016 Mar 31;7:e2164.

Etiology, Antibiotic Resistance and Risk Factors for Neonatal Sepsis in a Large Referral Center in Zambia. Kabwe M, Tembo J, Chilukutu L, Chilufya M, Ngulube F, Lukwesa C, Kapasa M, Enne V, Wexner H, Mwananyanda L, Hamer DH, Sinyangwe S, Ahmed Y, Klein N, Maeurer M, Zumla A, Bates M. Pediatr Infect Dis J. 2016 Mar 30.

World TB Day 2016—advancing global tuberculosis control efforts.  Zumla A,  Oliver M, Sharma V, Masham S, Herbert N. Lancet Infect Dis. in press PDF

World TB Day 2016: reflections on the global TB emergency. Zumla A, Schito M, Chakaya J,
Marais B, Mwaba P, Migliori G.B, Hoelscher M, Maeurer M, Wallis R. Lancet Resp Med. in press PDF

Progress towards achieving global tuberculosis control: so near, yet so far. Zumla A, Davies P. The International Journal of Tuberculosis and Lung Disease. in press PDF

The International Journal of Tuberculosis and Lung Disease. Marais B, Outhred A, Zumla A. Int J Infect Dis. in press. PDF

Host-directed therapies for infectious diseases: current status, recent progress, and future prospects. 
Zumla A, Rao M, Wallis R, Kaufmann S, Rustomjee R, Mwaba P, Vilaplana C, Yeboah-Manu D, Chakaya J, Ippolito G, Azhar E, Hoelscher M, Maeurer M, for the Host-Directed Therapies Network consortium*Lancet Infect Dis. in press PDF

Tuberculosis—advances in development of new drugs, treatment regimens, host-directed therapies, and biomarkers. Wallis R, Markus Maeurer, Peter Mwaba, Jeremiah Chakaya, Roxana Rustomjee, Giovanni Battista Migliori, Ben Marais, Marco Schito, Gavin Churchyard, Soumya Swaminathan, Michael Hoelscher, Alimuddin Zumla. Lancet Infect Dis. in press PDF

Tuberculosis and mass gatherings—opportunities for defining burden, transmission risk, and the optimal surveillance, prevention, and control measures at the annual Hajj pilgrimage. Alimuddin Zumla, Abdulaziz Bin Saeed, Badriah Alotaibi, Saber Yezli, Osman Dar, Kingsley Bieh, Matthew Bates, Tamara Tayeb, Peter Mwaba, Shuja Shafi , Brian McCloskey, Eskild Petersen, Esam I. Azhar. Int J Infect Dis. In press PDF

Host-directed therapies for antimicrobial resistant respiratory tract infections. Maeurer M, Rao M, Zumla A. Curr Opin Pulm Med. 2016 Mar 17.
Effectiveness and safety of meropenem/clavulanate-containing regimens in the treatment of MDR- and XDR-TB. Tiberi S, Payen MC, Sotgiu G, D'Ambrosio L, Alarcon Guizado V, Alffenaar JW, Abdo Arbex M, Caminero JA, Centis R, De Lorenzo S, Gaga M, Gualano G, Roby Arias AJ, Scardigli A, Skrahina A, Solovic I, Sulis G, Tadolini M, Akkerman OW, Alarcon Arrascue E, Aleska A, Avchinko V, Bonini EH, Chong Marín FA, Collahuazo López L, de Vries G, Dore S, Kunst H, Matteelli A, Moschos C, Palmieri F, Papavasileiou A, Spanevello A, Vargas Vasquez D, Viggiani P, White V, Zumla A, Migliori GB. Eur Respir J. 2016 Mar 10. PDF

Zika virus and microcephaly: is the correlation, causal or coincidental? Liuzzi G, Puro V, Vairo F, Nicastri E, Capobianchi MR, Di Caro A, Piacentini M, Zumla A, Ippolito G. New Microbiol. 2016 Mar 10;39(2).

Taking forward the World TB Day 2016 theme "Unite to End Tuberculosis" for the WHO Africa Region. Ntoumi F, Kaleebu P, Macete E, Mfinanga S, Chakaya J, Yeboah-Manu D, Bates M, Mwaba P, Maeurer M, Petersen E, Zumla A. Int J Infect Dis. 2016 Mar 8. PDF

Zika virus outbreak and the case for building effective and sustainable rapid diagnostics laboratory capacity globally. Zumla A, Goodfellow I, Kasolo F, Ntoumi F, Buchy P, Bates M, Azhar EI, Cotten M, Petersen E. Int J Infect Dis. 2016 Mar 4.

Translational Research for Tuberculosis Elimination: Priorities, Challenges, and Actions. Lienhardt C, Lönnroth K, Menzies D, Balasegaram M, Chakaya J, Cobelens F, Cohn J, Denkinger CM, Evans TG, Källenius G, Kaplan G, Kumar AM, Matthiessen L, Mgone CS, Mizrahi V, Mukadi YD, Nguyen VN, Nordström A, Sizemore CF, Spigelman M, Squire SB, Swaminathan S, Van Helden PD, Zumla A, Weyer K, Weil D, Raviglione M. PLoS Med. 2016 Mar 2;13(3)

Effectiveness and Safety of Imipenem-Clavulanate Added to an Optimized Background Regimen (OBR) Versus OBR Control Regimens in the Treatment of Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis. Tiberi S, Sotgiu G, D'Ambrosio L, Centis R, Arbex MA, Alarcon Arrascue E, Alffenaar JW, Caminero JA, Gaga M, Gualano G, Skrahina A, Solovic I, Sulis G, Tadolini M, Alarcon Guizado V, De Lorenzo S, Roby Arias AJ, Scardigli A, Akkerman OW, Aleksa A, Artsukevich J, Avchinko V, Bonini EH, Chong Marín FA, Collahuazo López L, de Vries G, Dore S, Kunst H, Matteelli A, Moschos C, Palmieri F, Papavasileiou A, Payen MC, Piana A, Spanevello A, Vargas Vasquez D, Viggiani P, White V, Zumla A, Migliori GB. Clin Infect Dis. 2016 Feb 16.

Tuberculosis and mass gatherings-opportunities for defining burden, transmission risk, and the optimal surveillance, prevention, and control measures at the annual Hajj pilgrimage. Zumla A, Saeed AB, Alotaibi B, Yezli S, Dar O, Bieh K, Bates M, Tayeb T, Mwaba P, Shafi S, McCloskey B, Petersen E, Azhar EI. Int J Infect Dis. 2016 Feb 9.

Coronaviruses — drug discovery and therapeutic options. Zumla A, Chan J, Ashar E, Hui D & Yuen KY. Nat Rev Drug Discov. 2016
Unexpected and Rapid Spread of Zika Virus in The Americas - Implications for Public Health Preparedness for Mass Gatherings at the 2016 Brazil Olympic Games. Petersen E, Wilson ME, Touch S, McCloskey B, Mwaba P, Bates M, Dar O, Mattes F, Kidd M, Ippolito G, Azhar EI, Zumla A. Int J Infect Dis. 2016 Feb 4.

The Prevalence of Tuberculosis in Zambia: Results from the First National TB Prevalence Survey, 2013-2014. Kapata N, Chanda-Kapata P, Ngosa W, Metitiri M, Klinkenberg E, Kalisvaart N, Sunkutu V, Shibemba A, Chabala C, Chongwe G, Tembo M, Mulenga L, Mbulo G, Katemangwe P, Sakala S, Chizema-Kawesha E, Masiye F, Sinyangwe G, Onozaki I, Mwaba P, Chikamata D, Zumla A, Grobusch MP.
PLoS One. 2016 Jan 15;11(1):

The development, evaluation and performance of molecular diagnostics for detection of Mycobacterium tuberculosis. Bates M, Zumla A. Expert Rev Mol Diagn. 2016 Mar;16(3):307-22.

Rapid Spread of Zika Virus in The Americas - Implications for Public Health Preparedness for Mass Gatherings at the 2016 Brazil Olympic Games. Petersen E, Wilson ME, Touch S, McCloskey B, Mwaba P, Bates M, Dar O, Mattes F, Kidd M, Ippolito G, Azhar EI, Zumla A. Int J Infect Dis. 2016 Mar;44:11-5.

Exploring the evidence base for national and regional policy interventions to combat resistance. Dar OA, Hasan R, Schlundt J, Harbarth S, Caleo G, Dar FK, Littmann J, Rweyemamu M, Buckley EJ, Shahid M, Kock R, Li HL, Giha H, Khan M, So AD, Bindayna KM, Kessel A, Pedersen HB, Permanand G, Zumla A, Røttingen JA, Heymann DL. Lancet. 2016 Jan 16;387(10015):285-95.