“Ukatamanga weka utamangisa, tikatamanga awili, tifikapatali - When you run alone, you run fast. When you run together, you run far Zambian Proverb

UNZA-UCLMS

Research and Training Programme

2013

Rapid diagnostics urgently needed for killer infections. Zumla A, Gant V, Bates M, Mwaba P, Maeurer M, Memish ZA. Lancet Respir Med. 2013 Jun;1(4):284-5.


Assessment of the sensitivity and specificity of Xpert MTB/RIF assay as an early sputum biomarker of response to tuberculosis treatment. Friedrich SO, Rachow A, Saathoff E, Singh K, Mangu CD, Dawson R, Phillips PP, Venter A, Bateson A, Boehme CC, Heinrich N, Hunt RD, Boeree MJ, Zumla A, McHugh TD, Gillespie SH, Diacon AH, Hoelscher M; Pan African Consortium for the Evaluation of Anti-tuberculosis Antibiotics (PanACEA). Lancet Respir Med. 2013 Aug;1(6):462-70. 


High rates of congenital cytomegalovirus (CMV) infections linked with maternal HIV infection among neonatal admissions at a large referral centre in sub-Saharan Africa. Mwaanza N, Chilukutu L, Tembo J, Kabwe M, Musonda K, Kapasa M, Chabala C, Sinyangwe S, Mwaba P, Zumla A, Bates M. Clin Infect Dis 2013 Nov 22 PDF


Advancing Priority Research on the Middle East Respiratory Syndrome Coronavirus. Hui DF, Zumla A. J Infect Dis. 2013 Nov 11


Reversing the tide of the UK tuberculosis epidemic. Zenner D, Zumla A, Gill P, Cosford P, Abubakar I. Lancet. 2013 Oct 19;382(9901):1311-2. PDF


How great is the risk of Middle East respiratory syndrome coronavirus to the global population?

Memish ZA, Zumla A, Al-Tawfiq JA. Expert Rev Anti Infect Ther. 2013 Oct;11(10):979-981. PDF


Transmission and evolution of the Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive genomic study. Matthew Cotten*, Simon J Watson*, Paul Kellam*, Abdullah A Al-Rabeeah, Hatem Q Makhdoom, Abdullah Assiri, Jaffar A Al-Tawfiq, Rafat F Alhakeem, Hossam Madani, Fahad A AlRabiah, Sami Al Hajjar, Wafa N Al-nassir , Ali Albarrak, Hesham Flemban, Hanan H Balkhy, Sarah Alsubaie, Anne L Palser, Astrid Gall, Rachael Bashford-Rogers, Andrew Rambaut, Alimuddin I Zumla*, Ziad A Memish* Lancet. Sept 2013 PDF


Multidrug-resistant TB in Zambia: review of national data from 2000 to 2011Kapata N, Chanda-Kapata P, Bates M, Mwaba P, Cobelens F, Grobusch M and Zumla A. Trop. Med. Int. Health. 11 SEP 2013 | DOI: 10.1111/tmi.12183 PDF


Therapeutic Options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) - possible lessons from a systematic review of SARS-CoV therapy. Momattin H, Mohammed K, Zumla A, Memish ZA, Al-Tawfiq JA. Int J Infect Dis. 2013 Aug 28. doi:pii: S1201-9712(13)00229-4. PDF


Middle East Respiratory Syndrome Coronavirus Infections in Health Care Workers.

Memish ZA, Zumla AI, Assiri A. N Engl J Med. 2013 Aug 7. PDF


Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study. Assiri A, Al-Tawfiq JA, Al-Rabeeah AA, Al-Rabiah FA, Al-Hajjar S, Al-Barrak A, Flemban H, Al-Nassir WN, Balkhy HH, Al-Hakeem RF, Makhdoom HQ, Zumla AI, Memish ZA. Lancet Infect Dis. 2013 Jul 25. PDF


Use of the Xpert® MTB/RIF assay for diagnosing pulmonary tuberculosis comorbidity and multidrug-resistant TB in obstetrics and gynaecology inpatient wards at the University Teaching Hospital, Lusaka, Zambia. Matthew Bates, Yusuf Ahmed, Lophina Chilukutu, John Tembo, Busiku Cheelo, Sylvester Sinyangwe, Nathan Kapata, Markus Maeurer, Justin O’Grady, Peter Mwaba, and Alimuddin Zumla. Trop Med Int Health. 3 JUL 2013 DOI: 10.1111/tmi.12145 PDF


Hospital Outbreak of Middle East Respiratory Syndrome Coronavirus. Assiri A, McGeer A, Perl TM, Price CS, Al Rabeeah AA, Cummings DA, Alabdullatif ZN, Assad M, Almulhim A, Makhdoom H, Madani H, Alhakeem R, Al-Tawfiq JA, Cotten M, Watson SJ, Kellam P, Zumla AI, Memish ZA; the KSA MERS-CoV Investigation Team. N Engl J Med. 2013 Jun 19. PDF


Family Cluster of Middle East Respiratory Syndrome Coronavirus Infections. Memish ZA, Zumla AI, Al-Hakeem RF, Al-Rabeeah AA, Stephens GM. N Engl J Med. 2013 May 29. PDF


Human Cytomegalovirus (HCMV) Infection in Sub-Saharan Africa, Matthew Bates, Kunda Musonda and Alimuddin Zumla (2013). Manifestations of Cytomegalovirus Infection, Prof. Patricia Price (Ed.), ISBN: 978-953-51-1116-0, InTech Open Access, PDF

Books & Series from 2013

Alimuddin Zumla: infectious diseases guru and survivor.

Kirby T. Lancet Infect Dis. 2013 Apr;13(4):301 PDF


Tuberculosis co-morbidity with communicable and non-communicable diseases: integrating health services and control efforts. Ben Marais, Knut Lönnroth, Stephen Lawn , Giovanni Battista Migliori, Peter Mwaba, Philippe Glaziou, Matthew Bates, Ruth Colagiuri, Lynn Zijenah, Soumya Swaminathan, Ziad Memish, Michel Pletschette, Michael Hoelscher, Ibrahim Abubakar, Guiseppe Pantale, Gill Crai, Peter Kim, Markus Maeurer, Marco Schito and Alimuddin Zumla. Lancet Infect Dis. 2013 Mar 22. PDF

 

Drug resistant tuberculosis – time for visionary political leadership. Ibrahim Abubakar, Matteo Zignol, Dennis Falzon, Professor Mario Raviglione, Lucica Ditiu, Baroness Susan Masham, Ifedayo Adetifa, Nathan Ford, Helen Cox, Stephen D. Lawn , Ben Marais, Professor Timothy D McHugh, Peter Mwaba, Matthew Bates, Marc Lipman, Lynn Zijenah, Simon Logan, Ruth McNerney, Adam Zumla, Krishna Sarda, Nahid Payam, Michael Hoelscher, Michel Pletschette,  Ziad Memish, Peter Kim, Richard Hafner , Stewart Cole, Giovanni-Battista Migliori, Markus Maeurer, Marco Schito, Alimuddin Zumla. Lancet Infect Dis. 2013 Mar 22. PDF

 

Advances in Tuberculosis Diagnostics: The Xpert MTB/RIF Assay and Future Prospects for a Point-of-Care Test.  Stephen D. Lawn , Peter Mwaba, Matthew Bates, Amy Piatek, Heather Alexander,  Ben J. Marais, Luis E. Cuevas, Timothy D. Mchugh, Lynn Zijenah, Nathan Kapata, Ibrahim Abubakar, Ruth McNerney, Michael Hoelscher, Ziad Memish, Giovanni Battista Migliori, Peter Kim, Professor Markus Maeurer, Marco Schito and Alimuddin Zumla.  Lancet Infect Dis. 2013 Apr;13(4):349-61 PDF


Tuberculosis  biomarkers discovery:  recent developments, needs and challenges. Robert S. Wallis,  Cunshan Wang, Payam Nahid, Stewart Cole, Debra Hanna, Peter Kim, Markus Maeurer, Marco Schito, and Alimuddin Zumla. Lancet Infect Dis. 2013 Apr;13(4):362-72. PDF

 

Aligning New TB Drug Regimens and Drug Susceptibility Testing: A Needs Assessment and Roadmap for Action. William A. Wells, Catharina C. Boehme, Frank G.J. Cobelens, Colleen Daniels, David Dowdy, Elizabeth Gardiner, Jan Gheuens, Peter Kim, Michael E. Kimerling, Barry Kreiswirth, Christian Lienhardt, Khisi Mdluli, Madhukar Pai, Mark D. Perkins, Trevor Peter, Bonnie Plikaytis, James E. Posey, Matteo Zignol, Alimuddin Zumla, Marco Schito on behalf of the TB Diagnostics Research Forum*. Lancet Infect Dis. 2013 Mar 22. PDF

 

Progress, challenges and concepts from childhood tuberculosis. Commentary: Ben J Marais, Stephen M Graham, Markus Maeurer, and Alimuddin Zumla. Lancet Infect Dis. 2013 Apr;13(4):287-9. PDF

 

Zero deaths from tuberculosis: progress, reality and hope. Alimuddin Zumla, Peter Kim, Markus Maeurer, Marco Schito. Lancet Infect Dis. 2013 Apr;13(4):285-7. PDF

Advances in the development of new tuberculosis drugs and treatment regimens. Zumla A, Nahid P, Cole ST. Nat Rev Drug Discov. 2013 May;12(5):388-404


Expression of TNF-Alpha-Dependent Apoptosis-Related Genes in the Peripheral Blood of Malagasy Subjects with Tuberculosis. Rakotosamimanana N, Doherty TM, Andriamihantasoa LH, Richard V, Gicquel B, Soares JL, Zumla A, Razanamparany VR. PLoS One. 2013 Apr 12;8(4)


Non-steroidal anti-inflammatory drugs for adjunctive tuberculosis treatment. Ivanyi J, Zumla A. J Infect Dis. 2013 Apr 5. PDF


Systems level immune response analysis and personalized medicine. Brodin P, Valentini D, Uhlin M, Mattsson J, Zumla A, Maeurer MJ. Expert Rev Clin Immunol. 2013 Apr;9(4):307-17


A Broad Profile of Co-Dominant Epitopes Shapes the Peripheral Mycobacterium tuberculosis Specific CD8+ T-Cell Immune Response in South African Patients with Active Tuberculosis. Axelsson-Robertson R, Loxton AG, Walzl G, Ehlers MM, Kock MM, Zumla A, Maeurer M. PLoS One. 2013;8(3)


Applying lessons from SARS to a newly identified coronavirus. McCloskey B, Zumla A, Stephens G, Heymann DL, Memish ZA. Lancet Infect Dis. 2013 Mar 20.


Differential cellular recognition pattern to M. tuberculosis targets defined by IFN-γ and IL-17 production in blood from TB + patients from Honduras as compared to health care workers: TB and immune responses in patients from Honduras. Alvarez-Corrales N, Ahmed RK, Rodriguez CA, Balaji KN, Rivera R, Sompallae R, Vudattu NK, Hoffner SE, Zumla A, Pineda-Garcia L, Maeurer M. BMC Infect Dis. 2013 Mar 6;13:125.


Epidemiology of Anti-tuberculosis Drug Resistance in Saudi Arabia: Findings of the First National Survey. Al-Hajoj S, Varghese B, Shoukri MM, Al-Omari R, Al-Herbwai M, Alrabiah F, Alrajhi AA, Abuljadayel N, Al-Thawadi S, Zumla A, Zignol M, Raviglione MC, Memish Z. Antimicrob Agents Chemother. 2013 Mar 4.


Current concepts: Tuberculosis. New England Journal of Medicine. Alimuddin Zumla,  Mario Raviglione, Richard Hafner, and C. Fordham von Reyn. 2013 Feb 21;368(8):745-55


History of tuberculosis and drug resistance. Marais BJ, Zumla A. N Engl J Med. 2013 Jan 3;368(1):88.


Assessment of the Xpert MTB/RIF assay for diagnosis of tuberculosis with gastric lavage aspirates in children in sub-Saharan Africa: a prospective descriptive study. Bates M, O'Grady J, Maeurer M, Tembo J, Chilukutu L, Chabala C, Kasonde R, Mulota P, Mzyece J, Chomba M, Mukonda L, Mumba M, Kapata N, Rachow A, Clowes P, Hoelscher M, Mwaba P, Zumla A. Lancet Infect Dis. 2013 Jan;13(1):36-42. PDF

Current Opinion if Pulmonary Medicine Series

Deaths due to respiratory tract infections in Africa: a review of autopsy studies. Bates M, Mudenda V, Mwaba P, Zumla A. Curr Opin Pulm Med. 2013 Feb 20.


Respiratory tract infections during the annual Hajj: potential risks and mitigation strategies. Al-Tawfiq JA, Zumla A, Memish ZA. Curr Opin Pulm Med. 2013 Feb 20


Current trends and newer concepts on diagnosis, management and prevention of respiratory tract infections. Zumla A. Curr Opin Pulm Med. 2013 Feb 18.


Advances in multiparametric molecular diagnostics technologies for respiratory tract infections. Reddington K, Tuite N, Barry T, O'Grady J, Zumla A. Curr Opin Pulm Med. 2013 Feb 18