“Ukatamanga weka utamangisa, tikatamanga awili, tifikapatali - When you run alone, you run fast. When you run together, you run far Zambian Proverb

UNZA-UCLMS

Research and Training Programme

Publications 2009...

An assessment of air as a source of DNA contamination encountered when performing PCR. Witt N, Rodger G, Vandesompele J, Benes V, Zumla A, Rook GA, Huggett JF. J Biomol Tech. 2009 Dec;20(5):236-40.

Biomarkers of disease activity, cure, and relapse in tuberculosis. Doherty TM, Wallis RS, Zumla A. Clin Chest Med. 2009 Dec;30(4):783-96,

Tuberculosis. Preface. Zumla A, Schaaf HS. Clin Chest Med. 2009 Dec;30(4):xiii-xviii.

Expression of apoptosis-related genes in an Ethiopian cohort study correlates with tuberculosis clinical status. Abebe M, Doherty TM, Wassie L, Aseffa A, Bobosha K, Demissie A, Zewdie M, Engers H, Andersen P, Kim L, Huggett J, Rook G, Yamuah LK, Zumla A; VACSEL study group. Eur J Immunol. 2010 Jan;40(1):291-301.

Implications of storing urinary DNA from different populations for molecular analyses. Cannas A, Kalunga G, Green C, Calvo L, Katemangwe P, Reither K, Perkins MD, Maboko L, Hoelscher M, Talbot EA, Mwaba P, Zumla AI, Girardi E, Huggett JF; TB trDNA consortium. PLoS One. 2009 Sep 10;4(9):e6985.

European bodies can help to tackle TB worldwide. Fears R, Zumla A, ter Meulen V. Nature. 2009 Aug 13;460(7257):796

Rapid diagnosis of tuberculosis through the detection of mycobacterial DNA in urine by nucleic acid amplification methods. Green C, Huggett JF, Talbot E, Mwaba P, Reither K, Zumla AI. Lancet Infect Dis. 2009 Aug;9(8):505-11. doi: 10.1016/S1473-3099(09)70149-5. Review. Erratum in: Lancet Infect Dis. 2009 Sep;9(9):536.

Quantitative lung T cell responses aid the rapid diagnosis of pulmonary tuberculosis. Dheda K, van Zyl-Smit RN, Meldau R, Meldau S, Symons G, Khalfey H, Govender N, Rosu V, Sechi LA, Maredza A, Semple P, Whitelaw A, Wainwright H, Badri M, Dawson R, Bateman ED, Zumla A. Thorax. 2009 Oct;64(10):847-53

European Union conference on poverty-related diseases research. Gryseels B, Zumla A, Troye-Blomberg M, Kieny MP, Quaglio G, Holtel A, Laang H, Romaris M, De Magistris MT, Nuez AN, Olesen OF, Ghalouci R, Lönnroth A. Lancet Infect Dis. 2009 Jun;9(6):334-7.

Biomarkers for tuberculosis disease status and diagnosis. Doherty M, Wallis RS, Zumla A; WHO-Tropical Disease Research/European Commission joint expert consultation group. Curr Opin Pulm Med. 2009 May;15(3):181-7. Review.

Utility of quantitative T-cell responses versus unstimulated interferon-{gamma} for the diagnosis of pleural tuberculosis. Dheda K, van Zyl-Smit RN, Sechi LA, Badri M, Meldau R, Meldau S, Symons G, Semple PL, Maredza A, Dawson R, Wainwright H, Whitelaw A, Vallie Y, Raubenheimer P, Bateman ED, Zumla A. Eur Respir J. 2009 Nov;34(5):1118-26.

Editorial: emerging respiratory infections in the 21st century. Zumla A. Curr Opin Pulm Med. 2009 May;15(3):179-80.

Within-subject variability and boosting of T-cell interferon-gamma responses after tuberculin skin testing. van Zyl-Smit RN, Pai M, Peprah K, Meldau R, Kieck J, Juritz J, Badri M, Zumla A, Sechi LA, Bateman ED, Dheda K. Am J Respir Crit Care Med. 2009 Jul 1;180(1):49-58

Nucleic acid detection and quantification in the developing world. Huggett J, Green C, Zumla A. Biochem Soc Trans. 2009 Apr;37(Pt 2):419-23.

Clinical diagnostic utility of IP-10 and LAM antigen levels for the diagnosis of tuberculous pleural effusions in a high burden setting. Dheda K, Van-Zyl Smit RN, Sechi LA, Badri M, Meldau R, Symons G, Khalfey H, Carr I, Maredza A, Dawson R, Wainright H, Whitelaw A, Bateman ED, Zumla A. PLoS One. 2009;4(3):e4689.

Reflections on the white plague. Zumla A, Mwaba P, Huggett J, Kapata N, Chanda D, Grange J. Lancet Infect Dis. 2009 Mar;9(3):197-202

Biomarkers for tuberculosis disease activity, cure, and relapse. Wallis RS, Doherty TM, Onyebujoh P, Vahedi M, Laang H, Olesen O, Parida S, Zumla A. Lancet Infect Dis. 2009 Mar;9(3):162-72.

The biosocial dynamics of tuberculosis. Grange JM, Kapata N, Chanda D, Mwaba P, Zumla A. Trop Med Int Health. 2009 Feb;14(2):124-30

Tuberculosis due to high-dose challenge in partially immune individuals: a problem for vaccination? Rook GA, Hernández-Pando R, Zumla A. J Infect Dis. 2009 Mar 1;199(5):613-8.

BCG vaccination in children. von Reyn CF, Zumla AI. BMJ. 2008 Nov 13;337:a2086.

Differential susceptibility of PCR reactions to inhibitors: an important and unrecognised phenomenon. Huggett JF, Novak T, Garson JA, Green C, Morris-Jones SD, Miller RF, Zumla A. BMC Res Notes. 2008 Aug 28;1:70

Role of co-trimoxazole prophylaxis in reducing mortality in HIV infected adults being treated for tuberculosis: randomised clinical trial. Nunn AJ, Mwaba P, Chintu C, Mwinga A, Darbyshire JH, Zumla A; UNZA-UCLMS Project LUCOT Collaboration. BMJ. 2008 Jul 10;337:a257.

Gene expression of IL17 and IL23 in the lungs of patients with active tuberculosis. Dheda K, Chang JS, Lala S, Huggett JF, Zumla A, Rook GA. Thorax. 2008 Jun;63(6):566-8.

Current opinions on selected respiratory infections causing global morbidity and mortality. Zumla A. Curr Opin Pulm Med. 2008 May;14(3):165-7.

Tuberculosis--the tide can be turned, the battle can be won. Zumla A. J R Soc Med. 2008 Mar;101(3):100-1.

Establishing a new service role in tuberculosis care: the tuberculosis link worker. Craig GM, Booth H, Hall J, Story A, Hayward A, Goodburn A, Zumla A. J Adv Nurs. 2008 Feb;61(4):413-24.

Ex vivo cytokine mRNA levels correlate with changing clinical status of ethiopian TB patients and their contacts over time. Wassie L, Demissie A, Aseffa A, Abebe M, Yamuah L, Tilahun H, Petros B, Rook G, Zumla A, Andersen P, Doherty TM; VACSEL Study Group. PLoS One. 2008 Jan 30;3(1):e1522.

Steroid metabolism and immunity: therapeutic implications. Rook GA, Baker R, Zumla A. BioDrugs. 1997 Sep;8(3):157-63.

Population differences in death rates in HIV-positive patients with tuberculosis. nCiglenecki I, Glynn JR, Mwinga A, Ngwira B, Zumla A, Fine PE, Nunn A. nInt J Tuberc Lung Dis. 2007 Oct;11(10):1121-8.

The pathogen recognition sensor, NOD2, is variably expressed in patients with pulmonary tuberculosis. Lala S, Dheda K, Chang JS, Huggett JF, Kim LU, Johnson MA, Rook GA, Keshav S, Zumla A. BMC Infect Dis. 2007 Aug 16;7:96.

Development and evaluation of a real-time PCR assay for detection of Pneumocystis jirovecii DNA in bronchoalveolar lavage fluid of HIV-infected patients. Huggett JF, Taylor MS, Kocjan G, Evans HE, Morris-Jones S, Gant V, Novak T, Costello AM, Zumla A, Miller RF. Thorax. 2008 Feb;63(2):154-9. Epub 2007 Aug 10. Erratum in: Thorax. 2009 Jul;64(7):643.

Educational outreach to promote screening for tuberculosis in primary care: a cluster randomised controlled trial. Griffiths C, Sturdy P, Brewin P, Bothamley G, Eldridge S, Martineau A, MacDonald M, Ramsay J, Tibrewal S, Levi S, Zumla A, Feder G. Lancet. 2007 May 5;369(9572):1528-34.

FOXP3 gene expression in a tuberculosis case contact study. Burl S, Hill PC, Jeffries DJ, Holland MJ, Fox A, Lugos MD, Adegbola RA, Rook GA, Zumla A, McAdam KP, Brookes RH. Clin Exp Immunol. 2007 Jul;149(1):117-22. Epub 2007 Apr 26.

Interpretation of Mycobacterium tuberculosis antigen-specific IFN-gamma release assays (T-SPOT.TB) and factors that may modulate test results. Dheda K, Pooran A, Pai M, Miller RF, Lesley K, Booth HL, Scott GM, Akbar AN, Zumla A, Rook GA. J Infect. 2007 Aug;55(2):169-73. Epub 2007 Apr 19.

The impact of social factors on tuberculosis management. Craig GM, Booth H, Story A, Hayward A, Hall J, Goodburn A, Zumla A. J Adv Nurs. 2007 Jun;58(5):418-24. Epub 2007 Apr 17.

The stability of mRNA encoding IL-4 is increased in pulmonary tuberculosis, while stability of mRNA encoding the antagonistic splice variant, IL-4delta2, is not. Dheda K, Chang JS, Huggett JF, Kim LU, Johnson MA, Zumla A, Rook GA.Tuberculosis (Edinb). 2007 May;87(3):237-41. Epub 2006 Dec 29.

Problems of developing molecular diagnostic tests for opportunistic pathogens: the example of Pneumocystis jirovecii. Huggett JF, Miller RF, Taylor MS, Costello AM, Zumla A. J Eukaryot Microbiol. 2006;53 Suppl 1:S85-6. No abstract available.

Effect of cotrimoxazole on causes of death, hospital admissions and antibiotic use in HIV-infected children. Mulenga V, Ford D, Walker AS, Mwenya D, Mwansa J, Sinyinza F, Lishimpi K, Nunn A, Gillespie S, Zumla A, Chintu C, Gibb DM; CHAP Trial Team. AIDS. 2007 Jan 2;21(1):77-84.

Expression of IL-4 mRNA in peripheral blood mononuclear cells from normal donors in relation to expression of TLR2. Chang JS, Dheda K, Huggett JF, Kim LU, Zumla A, Rook GA. Immunol Lett. 2006 Aug 15;106(2):194-7. Epub 2006 Jun 27.

The 6-kilodalton early secreted antigenic target-responsive, asymptomatic contacts of tuberculosis patients express elevated levels of interleukin-4 and reduced levels of gamma interferon. Demissie A, Wassie L, Abebe M, Aseffa A, Rook G, Zumla A, Andersen P, Doherty TM; VACSEL Study Group. Infect Immun. 2006 May;74(5):2817-22.

Infectious diseases. Zumla A. Curr Opin Pulm Med. 2006 May;12(3):165-6. No abstract available.

Progress towards improved tuberculosis diagnostics for developing countries. Perkins MD, Roscigno G, Zumla A. Lancet. 2006 Mar 18;367(9514):942-3. No abstract available.

Turning the tide against tuberculosis. Zumla A, Mullan Z. Lancet. 2006 Mar 18;367(9514):877-8. No abstract available.

Immune systems in developed and developing countries; implications for the design of vaccines that will work where BCG does not. Rook GA, Dheda K, Zumla A. Tuberculosis (Edinb). 2006 May-Jul;86(3-4):152-62. Epub 2006 Feb 28. Review.

Myobacterium tuberculosis induces selective up-regulation of TLRs in the mononuclear leukocytes of patients with active pulmonary tuberculosis. Chang JS, Huggett JF, Dheda K, Kim LU, Zumla A, Rook GA. J Immunol. 2006 Mar 1;176(5):3010-8.

Recognition of stage-specific mycobacterial antigens differentiates between acute and latent infections with Mycobacterium tuberculosis. Demissie A, Leyten EM, Abebe M, Wassie L, Aseffa A, Abate G, Fletcher H, Owiafe P, Hill PC, Brookes R, Rook G, Zumla A, Arend SM, Klein M, Ottenhoff TH, Andersen P, Doherty TM; VACSEL Study Group. Clin Vaccine Immunol. 2006 Feb;13(2):179-86.

An improved fluorescent amplified fragment length polymorphism method for typing Mycobacterium tuberculosis. Kassama Y, Shemko M, Shetty N, Fang Z, Macintire G, Gant V, Zumla A, Goodacre R. J Clin Microbiol. 2006 Jan;44(1):288-9. No abstract available.

Treatment of tuberculosis: present status and future prospects. Onyebujoh P, Zumla A, Ribeiro I, Rustomjee R, Mwaba P, Gomes M, Grange JM. Bull World Health Organ. 2005 Nov;83(11):857-65. Epub 2005 Nov 10. Review.

Performance of a T-cell-based diagnostic test for tuberculosis infection in HIV-infected individuals is independent of CD4 cell count. Dheda K, Lalvani A, Miller RF, Scott G, Booth H, Johnson MA, Zumla A, Rook GA. AIDS. 2005 Nov 18;19(17):2038-41.

BCG: the story continues. Lienhardt C, Zumla A. Lancet. 2005 Oct 22-28;366(9495):1414-6.

Expression of a novel cytokine, IL-4delta2, in HIV and HIV-tuberculosis co-infection. Dheda K, Chang JS, Breen RA, Haddock JA, Lipman MC, Kim LU, Huggett JF, Johnson MA, Rook GA, Zumla A. AIDS. 2005 Oct 14;19(15):1601-6.

Lung remodeling in pulmonary tuberculosis. Dheda K, Booth H, Huggett JF, Johnson MA, Zumla A, Rook GA. J Infect Dis. 2005 Oct 1;192(7):1201-9. Epub 2005 Aug 29. Review.

Immune responses to tuberculosis in developing countries: implications for new vaccines. Rook GA, Dheda K, Zumla A. Nat Rev Immunol. 2005 Aug;5(8):661-7. Review.

The implications of using an inappropriate reference gene for real-time reverse transcription PCR data normalization. Dheda K, Huggett JF, Chang JS, Kim LU, Bustin SA, Johnson MA, Rook GA, Zumla A. Anal Biochem. 2005 Sep 1;344(1):141-3.

Interferon gamma assays for tuberculosis. Dheda K, Chang JS, Kim LU, Huggett JF, Johnson MA, Zumla A, Rook GA. Lancet Infect Dis. 2005 Jun;5(6):324-5;

In vivo and in vitro studies of a novel cytokine, interleukin 4delta2, in pulmonary tuberculosis. Dheda K, Chang JS, Breen RA, Kim LU, Haddock JA, Huggett JF, Johnson MA, Rook GA, Zumla A. Am J Respir Crit Care Med. 2005 Aug 15;172(4):501-8.

Effect of sample handling on analysis of cytokine responses to Mycobacterium tuberculosis in clinical samples using ELISA, ELISPOT and quantitative PCR. Doherty TM, Demissie A, Menzies D, Andersen P, Rook G, Zumla A; VACSEL Study Group. J Immunol Methods. 2005 Mar;298(1-2):129-41.

Towards improving outcomes of fatal pulmonary infections. Zumla A. Curr Opin Pulm Med. 2005 May;11(3):187-8. No abstract available.

Real-time RT-PCR normalisation; strategies and considerations. Huggett J, Dheda K, Bustin S, Zumla A. Genes Immun. 2005 Jun;6(4):279-84. Review.

Do successful tuberculosis vaccines need to be immunoregulatory rather than merely Th1-boosting? Rook GA, Dheda K, Zumla A. Vaccine. 2005 Mar 18;23(17-18):2115-20. Review.

Study of familial Parkinson's disease in Russia, Uzbekistan, and Zambia. Atadzhanov M, Zumla A, Mwaba P. Postgrad Med J. 2005 Feb;81(952):117-21.

Crohn's disease and MAP. Huggett J, Dheda K, Zumla A, Rook G. Lancet. 2004 Dec 18-31;364(9452):2178; author reply 2178-9. No abstract available.

Effect of Mycobacterium vaccae (SRL172) immunotherapy on radiographic healing in tuberculosis. Johnson JL, Nunn AJ, Fourie PB, Ormerod LP, Mugerwa RD, Mwinga A, Chintu C, Ngwira B, Onyebujoh P, Zumla A. Int J Tuberc Lung Dis. 2004 Nov;8(11):1348-54.

Co-trimoxazole as prophylaxis against opportunistic infections in HIV-infected Zambian children (CHAP): a double-blind randomised placebo-controlled trial. Chintu C, Bhat GJ, Walker AS, Mulenga V, Sinyinza F, Lishimpi K, Farrelly L, Kaganson N, Zumla A, Gillespie SH, Nunn AJ, Gibb DM; CHAP trial team. Lancet. 2004 Nov 20-26;364(9448):1865-71.

Smoking is not beneficial for tuberculosis. Dheda K, Johnson MA, Zumla A, Rook GA. Am J Respir Crit Care Med. 2004 Oct 1;170(7):821; author reply 821. No abstract available.

Validation of housekeeping genes for normalizing RNA expression in real-time PCR. Dheda K, Huggett JF, Bustin SA, Johnson MA, Rook G, Zumla A. Biotechniques. 2004 Jul;37(1):112-4, 116, 118-9.

Increased expression of mRNA encoding interleukin (IL)-4 and its splice variant IL-4delta2 in cells from contacts of Mycobacterium tuberculosis, in the absence of in vitro stimulation. Fletcher HA, Owiafe P, Jeffries D, Hill P, Rook GA, Zumla A, Doherty TM, Brookes RH; Vacsel Study Group. Immunology. 2004 Aug;112(4):669-73.

Too hard on tropical medicine? Tomkins A, Zumla A, Pasvol G, Curtis C, Wright S. Lancet. 2004 Jul 3-9;364(9428):23. No abstract available.

Peripheral T cell interferon-gamma responses and latent tuberculosis. Dheda K, Rook G, Zumla A. Am J Respir Crit Care Med. 2004 Jul 1;170(1):97-8; author reply 98. No abstract available.

Healthy individuals that control a latent infection with Mycobacterium tuberculosis express high levels of Th1 cytokines and the IL-4 antagonist IL-4delta2. Demissie A, Abebe M, Aseffa A, Rook G, Fletcher H, Zumla A, Weldingh K, Brock I, Andersen P, Doherty TM; VACSEL Study Group. J Immunol. 2004 Jun 1;172(11):6938-43.

Type 2 cytokines in respiratory syncytial virus bronchiolitis. Dheda K, Huggett JF, Kim LU, Zumla A. Am J Respir Crit Care Med. 2004 May 15;169(10):1167-8; author reply 1168. No abstract available.

Infectious diseases. Zumla A. Curr Opin Pulm Med. 2004 May;10(3):157-8. Review. No abstract available.

BookPower. Zumla A, Fortescue S. Postgrad Med J. 2003 Dec;79(938):670.

Whole blood versus plasma spots for measurement of HIV-1 viral load in HIV-infected African patients. Mwaba P, Cassol S, Nunn A, Pilon R, Chintu C, Janes M, Zumla A. Lancet. 2003 Dec 20;362(9401):2067-8.

Use of dried whole blood spots to measure CD4+ lymphocyte counts in HIV-1-infected patients. Mwaba P, Cassol S, Pilon R, Chintu C, Janes M, Nunn A, Zumla A. Lancet. 2003 Nov 1;362(9394):1459-60.

Tuberculosis: amplification-based clinical diagnostic techniques. Huggett JF, McHugh TD, Zumla A. Int J Biochem Cell Biol. 2003 Oct;35(10):1407-12. Review.

Editorial overview: Infectious diseases. Zumla AI. Curr Opin Pulm Med. 2003 May;9(3):163-5.

The relentless spread of tuberculosis in Zambia--trends over the past 37 years (1964-2000). Mwaba P, Maboshe M, Chintu C, Squire B, Nyirenda S, Sunkutu R, Zumla A. S Afr Med J. 2003 Feb;93(2):149-52.

Mycobacterium vaccae (SRL172) immunotherapy as an adjunct to standard antituberculosis treatment in HIV-infected adults with pulmonary tuberculosis: a randomised placebo-controlled trial. Mwinga A, Nunn A, Ngwira B, Chintu C, Warndorff D, Fine P, Darbyshire J, Zumla A; LUSKAR collaboration. Lancet. 2002 Oct 5;360(9339):1050-5.

Lung diseases at necropsy in African children dying from respiratory illnesses: a descriptive necropsy study. Chintu C, Mudenda V, Lucas S, Nunn A, Lishimpi K, Maswahu D, Kasolo F, Mwaba P, Bhat G, Terunuma H, Zumla A; UNZA-UCLMS Project Paediatric Post-mortem Study Group. Lancet. 2002 Sep 28;360(9338):985-90.

T cell receptor usage in patients with non-progressing HIV infection. Bodman-Smith MD, Williams I, Johnstone R, Boylston A, Lydyard PM, Zumla A. Clin Exp Immunol. 2002 Oct;130(1):115-20.

Evaluation of PCR-based methods for the diagnosis of tuberculosis by identification of mycobacterial DNA in urine samples. Kafwabulula M, Ahmed K, Nagatake T, Gotoh J, Mitarai S, Oizumi K, Zumla A. Int J Tuberc Lung Dis. 2002 Aug;6(8):732-7.

The resurgence of disease: social and historical perspectives on the 'new' tuberculosis. Gandy M, Zumla A. Soc Sci Med. 2002 Aug;55(3):385-96; discussion 397-401.

The global emergency of tuberculosis: what is the cause? Grange JM, Zumla A. J R Soc Promot Health. 2002 Jun;122(2):78-81.

Drugs for neglected diseases. Zumla A. Lancet Infect Dis. 2002 Jul;2(7):393. No abstract available.

Non-tuberculous mycobacterial pulmonary infections. Zumla AI, Grange J. Clin Chest Med. 2002 Jun;23(2):369-76. Review.

Immunologic aspects of tropical lung disease. Zumla AI, James DG. Clin Chest Med. 2002 Jun;23(2):283-308, vii. Review.

Ethics of healthcare research in developing countries. Zumla A, Costello A. J R Soc Med. 2002 Jun;95(6):275-6. No abstract available.

Infection and disease caused by environmental mycobacteria. Zumla A, Grange J. Curr Opin Pulm Med. 2002 May;8(3):166-72. Review.

Identification of Pneumocystis carinii DNA by polymerase chain reaction in necropsy lung samples from children dying of respiratory tract illnesses. Kasolo F, Lishimpi K, Chintu C, Mwaba P, Mudenda V, Maswahu D, Terunuma H, Fletcher H, Nunn A, Lucas S, Zumla A. J Pediatr. 2002 Mar;140(3):367-9.

Identification of Pneumocystis carinii DNA in oropharyngeal mouth washes from AIDS children dying of respiratory illnesses. Lishimpi K, Kasolo F, Chintu C, Mwaba P, Mudenda V, Maswahu D, Terunuma H, Fletcher H, Nunn A, Lucas S, Zumla A. AIDS. 2002 Apr 12;16(6):932-4.

Multidrug-resistant tuberculosis--can the tide be turned? Zumla A, Grange JM. Lancet Infect Dis. 2001 Oct;1(3):199-202. Review.

Hydatid disease. Ustianowski AP, Zumla A. Clin Microbiol Infect. 1998 Jul;4(7):405-409. No abstract available.

Unique TCR beta-subunit variable gene haplotypes in Africans. Donaldson IJ, Shefta J, Lawson CA, Bushnell JR, Morgan AW, Isaacs JD, Carpenter D, Shaw MA, Rooth I, Quinnell RJ, Zumla AM, Ollier WR, Chintu CZ, Muyinda GP, Hill AS, Boylston AW. Immunogenetics. 2002 Feb;53(10-11):884-93. Epub 2002 Feb 1.

Clinical presentation, natural history, and cumulative death rates of 230 adults with primary cryptococcal meningitis in Zambian AIDS patients treated under local conditions. Mwaba P, Mwansa J, Chintu C, Pobee J, Scarborough M, Portsmouth S, Zumla A. Postgrad Med J. 2001 Dec;77(914):769-73.

Tuberculosis in disadvantaged groups. Grange J, Story A, Zumla A. Curr Opin Pulm Med. 2001 May;7(3):160-4. Review.

Advances in the immunopathogenesis of pulmonary tuberculosis. Rook GA, Zumla A. Curr Opin Pulm Med. 2001 May;7(3):116-23.

Necropsies in African children: consent dilemmas for parents and guardians. Lishimpi K, Chintu C, Lucas S, Mudenda V, Kaluwaji J, Story A, Maswahu D, Bhat G, Nunn AJ, Zumla A. Arch Dis Child. 2001 Jun;84(6):463-7.

Historical declines in tuberculosis: nature, nurture and the biosocial model. Grange JM, Gandy M, Farmer P, Zumla A. Int J Tuberc Lung Dis. 2001 Mar;5(3):208-12.

Local regulation of glucocorticoid activity in sites of inflammation. Insights from the study of tuberculosis. Rook G, Baker R, Walker B, Honour J, Jessop D, Hernandez-Pando R, Arriaga K, Shaw R, Zumla A, Lightman S. Ann N Y Acad Sci. 2000;917:913-22.

Predominance of one T-cell antigen receptor BV haplotype in African populations. Craddock TP, Zumla AM, Ollier WE, Chintu CZ, Muyinda GP, Lancaster FC, Boylston AW. Immunogenetics. 2000 Mar;51(3):231-7.

Increased cortisol: cortisone ratio in acute pulmonary tuberculosis. Baker RW, Walker BR, Shaw RJ, Honour JW, Jessop DS, Lightman SL, Zumla A, Rook GA. Am J Respir Crit Care Med. 2000 Nov;162(5):1641-7.

Moving to research partnerships in developing countries. Costello A, Zumla A. BMJ. 2000 Sep 30;321(7264):827-9.

Safety and immunogenicity of a five-dose series of inactivated Mycobacterium vaccae vaccination for the prevention of HIV-associated tuberculosis. Waddell RD, Chintu C, Lein AD, Zumla A, Karagas MR, Baboo KS, Habbema JD, Tosteson AN, Morin P, Tvaroha S, Arbeit RD, Mwinga A, von Reyn CF. Clin Infect Dis. 2000 Jun;30 Suppl 3:S309-15.

Four-year study of abdominal ultrasound in 900 Central African adults with AIDS referred for diagnostic imaging. Tshibwabwa ET, Mwaba P, Bogle-Taylor J, Zumla A. Abdom Imaging. 2000 May-Jun;25(3):290-6.

Advances in the management of tuberculosis: clinical trials and beyond. Grange JM, Zumla A. Curr Opin Pulm Med. 2000 May;6(3):193-7. Review.

Referral times of Vietnamese refugees with tuberculosis in camps in Hong Kong. Taylor WR, Zumla A. Int J Tuberc Lung Dis. 2000 Apr;4(4):350-5.

Impact of HIV infection on tuberculosis. Zumla A, Malon P, Henderson J, Grange JM. Postgrad Med J. 2000 May;76(895):259-68.

A study of maternal mortality at the University Teaching Hospital, Lusaka, Zambia: the emergence of tuberculosis as a major non-obstetric cause of maternal death. Ahmed Y, Mwaba P, Chintu C, Grange JM, Ustianowski A, Zumla A. Int J Tuberc Lung Dis. 1999 Aug;3(8):675-80.

Paradox of the global emergency of tuberculosis. Grange JM, Zumla A. Lancet. 1999 Mar 20;353(9157):996. No abstract available.

The tuberculosis pandemic: implications for health in the tropics. Zumla A, Squire SB, Chintu C, Grange JM. Trans R Soc Trop Med Hyg. 1999 Mar-Apr;93(2):113-7.

Protection from Pneumocystis carinii pneumonia. Day JH, Williams IG, Zumla A, Miller RF. Sex Transm Infect. 1999 Jun;75(3):202-3. No abstract available.

Tuberculosis and the poverty-disease cycle. Grange J, Zumla A. J R Soc Med. 1999 Mar;92(3):105-7. No abstract available.

The tuberculosis pandemic--which way now? Zumla A, Mwaba P, Squire SB, Grange JM. J Infect. 1999 Mar;38(2):74-9. Review. No abstract available.

Doing something about tuberculosis. Zumla A, Grange JM. BMJ. 1999 Apr 10;318(7189):956.

The effects of BCG immunization and human immunodeficiency virus infection on dual skin test reactions to purified protein derivative and Mycobacterium avium sensitin among adults in Zambia. Waddell RD, von Reyn CF, Baboo KS, Mwinga A, Chintu C, Zumla A. Int J Tuberc Lung Dis. 1999 Mar;3(3):255-60.

HIV-1 seroprevalence in Zambian patients with acute diarrhea: a community-based study. Baboo KS, Luo NP, Murphy JR, Cummings C, Chintu C, Ustianowski A, DuPont HL, Kelinowski M, Mathewson JJ, Zumla A. J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Feb 1;20(2):160-3.

Spread of Neisseria meningitidis group A clone III-I meningitis epidemic into Zambia. Luo N, Perera C, Holton J, Ayles H, Zumla A. J Infect. 1998 Mar;36(2):141-3.

Is the Gulf War syndrome an immunologically mediated phenomenon? Rook GA, Zumla A. Hosp Med. 1998 Jan;59(1):10-1. No abstract available.

Human immunodeficiency virus-associated diarrhea and wasting in Zambia: selected risk factors and clinical associations. Chintu C, Dupont HL, Kaile T, Mahmoud M, Marani S, Baboo KS, Mwansa W, Sakala-Kazembe F, Sunkutu R, Zumla A. Am J Trop Med Hyg. 1998 Jul;59(1):38-41.

Tuberculosis. Zumla A, Grange J. BMJ. 1998 Jun 27;316(7149):1962-4. Review.

Galloping consumption. Zumla A, Grange J. Nurs Times. 1998 Apr 8-14;94(14):14.

Establishing a united front against the injustice of tuberculosis. Zumla A, Grange JM. Int J Tuberc Lung Dis. 1998 Mar;2(3):179-81. No abstract available.

Tuberculosis--an epidemic of injustice. Grange J, Zumla A. J R Coll Physicians Lond. 1997 Nov-Dec;31(6):637-9. No abstract available.

Radiological features of pulmonary tuberculosis in 963 HIV-infected adults at three Central African Hospitals. Tshibwabwa-Tumba E, Mwinga A, Pobee JO, Zumla A. Clin Radiol. 1997 Nov;52(11):837-41.

Nosocomial transmission of tuberculosis in HIV/AIDS units in London. De Cock KM, Miller R, Zumla A, Holton J, Williams I. Genitourin Med. 1997 Aug;73(4):322.

Making DOTS succeed. Directly Observed Treatment, Short Course. Grange JM, Zumla A. Lancet. 1997 Jul 19;350(9072):157.

Gulf War syndrome: is it due to a systemic shift in cytokine balance towards a Th2 profile? Rook GA, Zumla A. Lancet. 1997 Jun 21;349(9068):1831-3.

Adrenal function and the hypothalamo-pituitary adrenal axis in immunodeficiency virus-associated tuberculosis. Baker R, Rook GA, Zumla A. Int J Tuberc Lung Dis. 1997 Jun;1(3):289-90. No abstract available.

Granulomatous infections: etiology and classification. Zumla A, James DG. Clin Infect Dis. 1996 Jul;23(1):146-58. Review.

Isolation of Campylobacter species from Zambian patients with acute diarrhoea. Luo NP, Baboo KS, Mwenya D, Diab A, Perera CU, Cummings C, Dupont HL, Murphy JR, Zumla A. East Afr Med J. 1996 Jun;73(6):395-6.

The spectrum of African Kaposi's sarcoma: is it consequential upon diverse immunological responses? Matondo P, Zumla A. Scand J Infect Dis. 1996;28(3):225-30. Review.

Impact of the human immunodeficiency virus type-1 on common pediatric illnesses in Zambia. Chintu C, Luo C, Bhat G, DuPont HL, Mwansa-Salamu P, Kabika M, Zumla A. J Trop Pediatr. 1995 Dec;41(6):348-53.

Pattern of adult malignancies in Zambia (1980-1989) in light of the human immunodeficiency virus type 1 epidemic. Patil P, Elem B, Zumla A. J Trop Med Hyg. 1995 Aug;98(4):281-4.

HEp-2 cell-adherent Escherichia coli in patients with human immunodeficiency virus-associated diarrhea. Mathewson JJ, Jiang ZD, Zumla A, Chintu C, Luo N, Calamari SR, Genta RM, Steephen A, Schwartz P, DuPont HL. J Infect Dis. 1995 Jun;171(6):1636-9.

Parasites and HIV-related diarrhoea. Zumla A, Chintu C. S Afr Med J. 1995 Jun;85(6):494-5.

Intestinal parasites in HIV-seropositive Zambian children with diarrhoea. Chintu C, Luo C, Baboo S, Khumalo-Ngwenya B, Mathewson J, DuPont HL, Zumla A. J Trop Pediatr. 1995 Jun;41(3):149-52.

Use of saliva as an alternative to serum for HIV screening in Africa. Luo N, Kasolo F, Ngwenya BK, du Pont HL, Zumla A. S Afr Med J. 1995 Mar;85(3):156-7.

Childhood tuberculosis and infection with the human immunodeficiency virus. Chintu C, Zumla A. J R Coll Physicians Lond. 1995 Mar-Apr;29(2):92-5. Review.

Gut parasites in HIV-seropositive Zambian adults with diarrhoea. Khumalo-Ngwenya B, Luo NP, Chintu C, Sunkutu R, Sakala-Kazembe F, Baboo KS, Mathewson J, Zumla A. East Afr Med J. 1994 Jun;71(6):379-83.

Common childhood illnesses and HIV infection in Africa. Zumla A, Chintu C, Luo C. S Afr Med J. 1994 May;84(5):296,298. No abstract available.

Tuberculosis and HIV infection. Zumla A, Chintu C. Lancet. 1994 Apr 2;343(8901):851-2. No abstract available.

Association of rotavirus and human immunodeficiency virus infection in children hospitalized with acute diarrhea, Lusaka, Zambia. Oshitani H, Kasolo FC, Mpabalwani M, Luo NP, Matsubayashi N, Bhat GH, Suzuki H, Numazaki Y, Zumla A, DuPont HL. J Infect Dis. 1994 Apr;169(4):897-900.

Human immunodeficiency virus type-1 infection in Zambian children with tuberculosis: changing seroprevalence and evaluation of a thioacetazone-free regimen. Luo C, Chintu C, Bhat G, Raviglione M, Diwan V, DuPont HL, Zumla A. Tuber Lung Dis. 1994 Apr;75(2):110-5.

Intestinal secretory IgA immune response against human immunodeficiency virus among infected patients with acute and chronic diarrhea. Mathewson JJ, Jiang ZD, DuPont HL, Chintu C, Luo N, Zumla A. J Infect Dis. 1994 Mar;169(3):614-7.

AIDS case definitions in developing countries. Chintu C, Zumla A. Lancet. 1993 Oct 23;342(8878):1054-5.

Anti-bovine viral diarrhoea virus antibodies in adult Zambian patients infected with the human immunodeficiency virus. Giangaspero M, Vacirca G, Morgan D, Baboo KS, Luo NP, DuPont HL, Zumla A. Int J STD AIDS. 1993 Sep-Oct;4(5):300-2.

Seroprevalence of human immunodeficiency virus type 1 infection in Zambian children with tuberculosis. Chintu C, Bhat G, Luo C, Raviglione M, Diwan V, Dupont HL, Zumla A. Pediatr Infect Dis J. 1993 Jun;12(6):499-504.

Cutaneous hypersensitivity reactions due to thiacetazone in the treatment of tuberculosis in Zambian children infected with HIV-I. Chintu C, Luo C, Bhat G, Raviglione M, DuPont H, Zumla A. Arch Dis Child. 1993 May;68(5):665-8.

Case definitions for paediatric AIDS: the Zambian experience. Chintu C, Malek A, Nyumbu M, Luo C, Masona J, DuPont HL, Zumla A. Int J STD AIDS. 1993 Mar-Apr;4(2):83-5.

Use of a murine T-cell hybridoma expressing human T-cell receptor alpha- and beta-gene products as a tool for the production of human T-cell receptor-specific monoclonal antibodies. Zumla A, McCormack A, George A, Batchelor R, Lechler R. Hum Immunol. 1992 Nov;35(3):141-8.

Superantigens--progress in understanding microbial pathogenesis. Zumla A, van den Bogaerde J. S Afr Med J. 1992 Sep;82(3):146-8.

Superantigens, T cells, and microbes. Zumla A. Clin Infect Dis. 1992 Aug;15(2):313-20. Review.

Co-expression of human T cell receptor chains with mouse CD3 on the cell surface of a mouse T cell hybridoma. Zumla A, Marguerie C, So A, Yokoyama WM, Saito T, Batchelor JR, Lechler RI. J Immunol Methods. 1992 Apr 27;149(1):69-76.

Chloroquine and proguanil prophylaxis in travellers to Kenya. Zumla A. Lancet. 1992 Jan 4;339(8784):62-3.

Chemotherapy and immunity in opportunistic parasitic infections in AIDS. Zumla A, Croft SL. Parasitology. 1992;105 Suppl:S93-101. Review..

T cell receptor expression in Sjögren's syndrome. Zumla A, Mathur M, Stewart J, Wilkinson L, Isenberg D. Ann Rheum Dis. 1991 Oct;50(10):691-3.

Mimics of sarcoidosis. Leprosy. Zumla A. Sarcoidosis. 1991 Sep;8(2):89-94. No abstract available.

Salmonella septic arthritis. Luo NP, Perera CU, Zumla A. J Infect. 1991 Jul;23(1):101. No abstract available.

Expression of a common idiotype PR4 in the sera of patients with leprosy. Zumla A, Williams W, Mudd D, Locniskar M, Behrens R, Isenberg D, McAdam KP. Clin Exp Immunol. 1991 Jun;84(3):522-6.

Toxoplasma serology in Zambian and Ugandan patients infected with the human immunodeficiency virus. Zumla A, Savva D, Wheeler RB, Hira SK, Luo NP, Kaleebu P, Sempala SK, Johnson JD, Holliman R. Trans R Soc Trop Med Hyg. 1991 Mar-Apr;85(2):227-9.

Surgery and Salmonella. Zumla A, Luo NP. BMJ. 1990 May 19;300(6735):1342. No abstract available.

Autoantibodies and tropical infections. Zumla A. Trans R Soc Trop Med Hyg. 1990 Jan-Feb;84(1):162-5. Review.

Topical zoonosis. Zumla A. J Infect. 1989 Nov;19(3):291. No abstract available.

Dysgonic fermenter type 2 infection. Zumla A. Lancet. 1989 Sep 9;2(8663):627. No abstract available.

Sarcoidosis and leprosy--an epidemiological, clinical, pathological and immunological comparison. Zumla A, James GD. Sarcoidosis. 1989 Sep;6(2):88-96. Review.

Malaria in spite of chemoprophylaxis. Lulat A, Zumla A. J Infect. 1989 Sep;19(2):186-7. No abstract available.

Honey--a remedy rediscovered. Zumla A, Lulat A. J R Soc Med. 1989 Jul;82(7):384-5. Review. No abstract available.

Spontaneous subcapsular splenic haematoma formation in infectious mononucleosis. Brown J, Marchant B, Zumla A. Postgrad Med J. 1989 Jun;65(764):427-8. No abstract available.

Purpura and sepsis--rarer causes? Zumla A, Lipscomb G. Br J Dermatol. 1989 May;120(5):715-6.

Malaria prophylaxis--a persisting dilemma. Zumla A, Laurenson I. J Antimicrob Chemother. 1989 May;23(5):809-10. No abstract available.

DF-2 infection. McCarthy M, Zumla A. BMJ. 1988 Nov 26;297(6660):1355-6. Review. No abstract available.

Sixth cranial nerve palsy complicating psittacosis. Zumla A, Lipscomb G, Lewis D. J Neurol Neurosurg Psychiatry. 1988 Nov;51(11):1462. No abstract available.

Dysgonic Fermenter-type 2: an emerging zoonosis. Report of two cases and review. Zumla A, Lipscomb G, Corbett M, McCarthy M. Q J Med. 1988 Sep;68(257):741-52. Review.

Studies of a common idiotype PR4 in autoimmune rheumatic disease. Williams W, Zumla A, Behrens R, Locniskar M, Voller A, McAdam KP, Isenberg DA. Arthritis Rheum. 1988 Sep;31(9):1097-104.

Legionnaires' disease: early lessons from 1988 London outbreak. Zumla A, Weyell R, Tettmar RE. Lancet. 1988 Jun 4;1(8597):1275. No abstract available.

Human monoclonal antibodies to phenolic glycolipid-I derived from patients with leprosy, and production of specific anti-idiotypes. Locniskar M, Zumla A, Mudd DW, Isenberg DA, Williams W, McAdam KP. Immunology. 1988 Jun;64(2):245-51.

Ciprofloxacin treatment of recurrent Salmonella typhimurium septicaemia in a splenectomized and immunosuppressed patient. Zumla A, Lewis D, Brown J. J Antimicrob Chemother. 1988 Jun;21(6):809-10.

Human monoclonal antibodies to phenolic glycolipid-1 from leprosy patients cross react with poly(ADP-ribose), polynucleotides and tissue bound antigens. Zumla A, Williams W, Shall S, Locniskar M, Leigh I, McAdam KP, Isenberg D. Autoimmunity. 1988;1(3):183-95.

A serological study on primary hepatocellular carcinoma in Zambia. Zumla A, Voller A. Trans R Soc Trop Med Hyg. 1982;76(4):546-51.